Iron metabolism as a key in the bone-cardiovascular crosstalk in Renal Osteodystrophy

Patients with chronic kidney disease (CKD, 5-10% population) develop a mineral and bone disease (CKD-MBD) with alterations in bone physiology and structure, termed ‘renal osteodystrophy’. CKD-MBD exposes to a higher risk of fracture, pain, fatigue, poor quality of life. Prevalence of fractures has increased for the past 30 years, in part due to advanced age to start dialysis and kidney replacement, and overall the longer lifespan of patients with CKD. In the global population, the place of CKD as a cause of mortality has increased by 41% between 1990 and 2017, and is the 10th cause of death overall, expected to rise to the 5th place by 2040.